Interferon‐β Modulates Inflammatory Response in Cerebral Ischemia
نویسندگان
چکیده
منابع مشابه
Interferon-b Modulates Inflammatory Response in Cerebral Ischemia
Background-—Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-b (IFNb), a cytokine with immunomodulatory properties, was approved by the US Food and Drug Administration for the treatment of relapsing-rem...
متن کاملInterferon‐β Modulates Inflammatory Response in Cerebral Ischemia
BACKGROUND Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-β (IFNβ), a cytokine with immunomodulatory properties, was approved by the US Food and Drug Administration for the treatment of relapsing-remi...
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Global cerebral ischemia (GCI) leads to inflammation and neuronal death in CA1. Curcumin with neuroprotective and anti-inflammatory properties is a potential candidate for suppressing cell death. The aim of this study was to determine the effects of curcumin on neuronal number in the CA1 area following GCI. 28 Sprague-Dawley male rats were randomly assigned into four groups including sham, cont...
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Stroke is associated with high morbidity and mortality, and much remains unknown about the injury-related mechanisms that occur following reperfusion. This study aimed to explore the roles of Toll-like receptor 2 (TLR2) and sphingosine kinase 1 (Sphk1) in microglial cells in inflammatory responses induced by cerebral ischemia/reperfusion (I/R). For this purpose, C57BL/6 mice were randomly divid...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2016
ISSN: 2047-9980,2047-9980
DOI: 10.1161/jaha.115.002610